Wednesday, March 6, 2013

Garcetti defeats deformer Greuel in LA mayoralty primary

Latest mayoral race results in from Los Angeles, for mayor, to succeed antagonist of teachers' union, mayor Antonio Villaraigosa:

Eric Garcetti (Democrat), by 10,000 votes, defeated education deformer Wendy Greuel (Democrat), who supports parent trigger laws.
He was endorsed by United Teachers Los Angeles, the teachers union.
Just as outsider money is influencing the city's school board race, expect school deform big money to come into the race in the second round. Because both Garcetti and Greuel fell far short of 50 percent, they must face off again in a runoff election.

Los Angeles primary results, March 5, 2013 Last updated: March 6, 2013, 2:30 a.m. PST Winner Advances to runoff (I) Incumbent L.A. Mayor
Precincts reporting: 100.0% (1,311/1,311)
Name Votes Pct.
Eric Garcetti 93,978 32.9%
Wendy Greuel 83,308 29.2%
Kevin James 46,684 16.4%
Jan Perry 45,480 15.9%
Emanuel Pleitez 11,716 4.1%
Norton Sandler 1,598 0.6%
Addie M. Miller 1,401 0.5%
Yehuda Draiman 1,174 0.4%

Tuesday, March 5, 2013

Circadian Disruption Leads to Insulin Resistance and Obesity

Circadian Disruption Leads to Insulin Resistance and Obesity

Current Biology, Volume 23, Issue 5, 372-381, 21 February 2013
Copyright © 2013 Elsevier Ltd All rights reserved.


Shu-qun Shi, Tasneem S. Ansari, Owen P. McGuinness, David H. Wasserman, Carl Hirschie JohnsonSee Affiliations
Insulin action shows a bona fide circadian rhythm Mice are most resistant to insulin during their daily phase of relative inactivity Disruption of circadian clocks predisposes animals to insulin resistance and obesity Function of insulin sensitive tissue depends upon the rhythmic internal environment
Disruption of circadian (daily) timekeeping enhances the risk of metabolic syndrome, obesity, and type 2 diabetes. While clinical observations have suggested that insulin action is not constant throughout the 24 hr cycle, its magnitude and periodicity have not been assessed. Moreover, when circadian rhythmicity is absent or severely disrupted, it is not known whether insulin action will lock to the peak, nadir, or mean of the normal periodicity of insulin action.
We used hyperinsulinemic-euglycemic clamps to show a bona fide circadian rhythm of insulin action; mice are most resistant to insulin during their daily phase of relative inactivity. Moreover, clock-disrupted Bmal1-knockout mice are locked into the trough of insulin action and lack rhythmicity in insulin action and activity patterns. When rhythmicity is rescued in the Bmal1-knockout mice by expression of the paralogous gene Bmal2, insulin action and activity patterns are restored. When challenged with a high-fat diet, arhythmic mice (either Bmal1-knockout mice or wild-type mice made arhythmic by exposure to constant light) were obese prone. Adipose tissue explants obtained from high-fat-fed mice have their own periodicity that was longer than animals on a chow diet.
This study provides rigorous documentation for a circadian rhythm of insulin action and demonstrates that disturbing the natural rhythmicity of insulin action will disrupt the rhythmic internal environment of insulin sensitive tissue, thereby predisposing the animals to insulin resistance and obesity.